| Annotated protein: | Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (Lymphocyte cell-specific protein-tyrosine kinase) (p56-LCK). Gene symbol: LCK. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q01621 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LCK |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic specialization, intracellular component (GO:0099091) |
| Synapse type(s): | brain, glutamatergic |
| Annotated paper: | Kalia LV, et al. "Interactions between Src family protein tyrosine kinases and PSD-95" Neuropharmacology. 2003 Nov;45(6):720-8 PMID:14529711 |
| Figure(s): | Fig. 1 |
| Annotation description: | Fig. 1. Lck protein tyrosine kinase is enriched in the PSD fraction. Literal: "The subcellular distribution of Src has been previously determined (Huang et al., 2001) and thus Src was used as a positive control in these experiments. The pattern of relative abundance of Lck and Lyn in the various subcellular fractions, as compared with the starting homogenate (H), was similar to that of Src (Fig. 1A). In contrast, the pattern of relative abundance of Yes was distinct from that of Src (Fig. 1A) but similar to that of Fyn (not illustrated)." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Western blot Biochemical fractionation (generic) |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| SynGO annotation ID: | 1910 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |