| Annotated protein: | Phospholipid phosphatase-related protein type 4 (Brain-specific phosphatidic acid phosphatase-like protein 1) (Inactive 2-lysophosphatidate phosphatase PLPPR4) (Lipid phosphate phosphatase-related protein type 4) (Plasticity-related gene 1 protein) (PRG-1). Gene symbol: PLPPR4. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q7TME0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PLPPR4 |
| Ontology domain: | Biological Process |
| SynGO term: | modulation of chemical synaptic transmission (GO:0050804) |
| Synapse type(s): | hippocampus, glutamatergic Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Liu X, et al. "PRG-1 Regulates Synaptic Plasticity via Intracellular PP2A/beta1-Integrin Signaling" Dev Cell. 2016 Aug 8;38(3):275-90 PMID:27453502 |
| Figure(s): | Fig. 3 |
| Annotation description: | PRG-1 (gene PLPPR4) and PP2A interaction induces Integrin beta-1 activation, regulates spine density, and enhances LTP. Blockage of interaction of PRG-1 and PP2A attenuates integrin beta-1 activation (A-C). Activation of PP2A complements PRG-1 deficiency (E-K). The signaling pathway influences LTP in hippocampal CA1 synapses. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal Field recordings |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | This paper shows that PP2A activity is involved in LTP at hippocampal synapses (Ticket ID 2397). @ PMID:10646534 PGR-1 (gene PLPPR4) characterization @ PMID:12730698 |
| SynGO annotation ID: | 1909 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |