| Annotated protein: | Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B]. Gene symbol: PLAT. Taxonomy: Mus musculus (Mouse). Uniprot ID: P11214 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PLAT |
| Ontology domain: | Biological Process |
| SynGO term: | trans-synaptic signaling by BDNF, modulating synaptic transmission (GO:0099183) |
| Synapse type(s): | hippocampus, glutamatergic Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Pang PT, et al. "Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity" Science. 2004 Oct 15;306(5695):487-91 PMID:15486301 |
| Figure(s): | Fig. 1E, 2B, 4A,B |
| Annotation description: | tPA is involved via activation of plasmin (Fig. 4B) to convert proBDNF into the mature mBDNF. tPA-/- mice are deficient for L-LTP, which can be rescued by either application of tPA itself (Fig. 4A) or mBDNF (Fig. 1E). proBDNF is not able to rescue this phenotype (Fig. 2B) but needs the protease plasmin (Fig. 4B). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | tPA is required for LTP. @ PMID:12270047 |
| SynGO annotation ID: | 1907 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |