| Annotated protein: | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16). Gene symbol: PPP2CA. Taxonomy: Mus musculus (Mouse). Uniprot ID: P63330 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PPP2CA |
| Ontology domain: | Cellular Component |
| SynGO term: | synapse (GO:0045202) |
| Synapse type(s): | brain cerebellum |
| Annotated paper: | Costanzo RV, et al. "Anp32e/Cpd1 regulates protein phosphatase 2A activity at synapses during synaptogenesis" Eur J Neurosci. 2006 Jan;23(2):309-24 PMID:16420440 |
| Figure(s): | Fig. 3A |
| Annotation description: | Figure 3A. (A) Analysis of protein phosphatases PP1, PP2A and Anp32e / Cpd1 was performed by Western blotting assays in homogenates and synaptic fractions at P7, P12 and P17. The homogenate and the synaptic fraction contain similar amounts of PP2Ac or PP1c catalytic subunits at all stages studied. Subcellular fractionation was performed from adult murine brains and cerebella. 13/11/2017 Pim - Auhtors use the term PP2A, and show the localization of this protein complex with a PP2Ac antibody. - Authors also show localization to dendrites via IF (Fig.6) |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Western blot Biochemical fractionation (generic) |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| SynGO annotation ID: | 1892 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |