| Annotated protein: | Protein turtle homolog B (Immunoglobulin superfamily member 9B). Gene symbol: IGSF9B. Taxonomy: Mus musculus (Mouse). Uniprot ID: E9PZ19 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ IGSF9B |
| Ontology domain: | Biological Process |
| SynGO term: | synapse adhesion between pre- and post-synapse (GO:0099560) |
| Synapse type(s): | hippocampus, GABAergic |
| Annotated paper: | Woo J, et al. "The adhesion protein IgSF9b is coupled to neuroligin 2 via S-SCAM to promote inhibitory synapse development" J Cell Biol. 2013 Jun 10;201(6):929-44 PMID:23751499 |
| Figure(s): | Fig. 3, 4 |
| Annotation description: | 9/11/2017 Pim Fig.3 IgSF9b mediates homophilic adhesion but is not sufficient to induce synapse formation (tested in HEK cells and recomb. Fc fused protein) Fig.4: IgSF9b knockdown reduces the number of VGAT-positive gephyrin clusters and the frequency of inhibitory synaptic transmission in interneurons. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| SynGO annotation ID: | 1886 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |