| Annotated protein: | Adhesion G protein-coupled receptor B1 (Brain-specific angiogenesis inhibitor 1) [Cleaved into: Vasculostatin-120 (Vstat120); Vasculostatin-40 (Vstat-40)]. Gene symbol: ADGRB1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: C0HL12 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ADGRB1 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic actin cytoskeleton organization (GO:0098974) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Duman JG, et al. "The adhesion-GPCR BAI1 regulates synaptogenesis by controlling the recruitment of the Par3/Tiam1 polarity complex to synaptic sites" J Neurosci. 2013 Apr 17;33(16):6964-78 PMID:23595754 |
| Figure(s): | fig 7, 9, 10, 11 |
| Annotation description: | 9/11/2017 Pim Fig. 7: BAI1 interacts with cell polarity machinery. Fig.9: Loss of BAI1 alters Rac1 activation and F-actin in hippocampal neurons. Fig.10: BAI1 interaction with Par3/Tiam1 is required for spinogenesis and Par3 localization. Fi.g11: BAI1 signals to Rac1 through Tiam1. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal IP + WB/MSMS Y2H |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| SynGO annotation ID: | 1883 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |