| Annotated protein: | Large ribosomal subunit protein eL30 (60S ribosomal protein L30). Gene symbol: RPL30. Taxonomy: Homo sapiens (Human). Uniprot ID: P62888 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RPL30 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | brain neocortex |
| Annotated paper: | Bayes A, et al. "Characterization of the proteome, diseases and evolution of the human postsynaptic density" Nat Neurosci. 2011 Jan;14(1):19-21 PMID:21170055 |
| Figure(s): | Table S2 |
| Annotation description: | The authors isolated hPSD from neocortical biopsies of nine adults (Supplementary Table 1 and Supplementary Fig. 1a) and performed proteomic profiling using LC-MS/MS to comprehensively identify a total of 1,461 proteins (total hPSD), 748 of which were detected in all three replicates (consensus hPSD, used for all subsequent analysis, except where explicitly stated otherwise; Supplementary Table 2). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | none of the above |
| Evidence tracking, Experiment Assay: | Mass-spectrometry Biochemical fractionation (generic) |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| Additional literature: | Using ion-mobility enhanced data-independent label-free LC-MS/MS, the authors established a reference proteome of crude synaptosomes, synaptic junctions, and PSD derived from mouse hippocampus including TOP3-based absolute quantification values for identified proteins. The final dataset across all fractions comprised 49 491 peptides corresponding to 4558 protein groups. Rpl30 appears in Table S1. @ PMID:25211037 |
| SynGO annotation ID: | 1874 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |