| Annotated protein: | Potassium voltage-gated channel subfamily A member 1 (RBKI) (RCK1) (Voltage-gated potassium channel subunit Kv1.1). Gene symbol: KCNA1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P10499 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ KCNA1 |
| Ontology domain: | Biological Process |
| SynGO term: | voltage-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099508) |
| Annotated paper: | Deal KK, et al. "The brain Kv1.1 potassium channel: in vitro and in vivo studies on subunit assembly and posttranslational processing" J Neurosci. 1994 Mar;14(3 Pt 2):1666-76 PMID:8126562 |
| Figure(s): | figure 4, figure 9 |
| Annotation description: | Expression of channels in Mouse L-cells (fybroblasts). rule: NAS_MFCC-BP rationale: Protein has voltage-gated ion channel activity and is localized in teh presynaptic membrane (show with high-resolution technique). The inference to term 'voltage-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099508)' is trivial and non-controversial. Pinf_CC: [P10499] SyNGO ID 179 (PMID:14614103, confocal) |
| Evidence tracking, Biological System: | Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Non-tracable Author Statement (NAS): | This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors. |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 187 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |