| Annotated protein: | NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase). Gene symbol: NTRK3. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q03351 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NTRK3 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic membrane (GO:0099055) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Takahashi H, et al. "Postsynaptic TrkC and presynaptic PTPsigma function as a bidirectional excitatory synaptic organizing complex" Neuron. 2011 Jan 27;69(2):287-303 PMID:21262467 |
| Figure(s): | Fig. 3, 5 |
| Annotation description: | 7/11/2017 Pim Fig.3: "Immunofluorescence analysis also revealed TrkC immunoreactivity in a punctate pattern in neuropil of adult mouse brain. Moreover, TrkC puncta were apposed to VGLUT1 puncta but not to gephyrin puncta, as shown here for hippocampal CA1 region (Figures 3G-3I)." Fig.4: "PTPσ-Fc-coated beads that contacted dendrites induced clustering of endogenous dendritic TrkC with NMDA receptor subunit NR1 (Figure 4F)." - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| SynGO annotation ID: | 1842 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |