| Annotated protein: | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (SPA-1-like protein p1294) (Spine-associated Rap GTPase-activating protein) (SPAR). Gene symbol: SIPA1L1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: O35412 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SIPA1L1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic density assembly (GO:0099151) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Pak DT, et al. "Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP" Neuron. 2001 Aug 2;31(2):289-303 PMID:11502259 |
| Figure(s): | Fig.4, Fig 5 |
| Annotation description: | 7/11/2017 Pim Fig.4: SPAR Recruits PSD-95 to F-Actin in COS cells Fig.5: SPAR is co-localized with PSD-95 in dendritic spines, and SPAR-enlarged spines showed more intense staining for PSD-95 (Figure 5E2, arrow) compared to spines of untransfected cells (Figure 5E2, arrowhead). Together this means that SPAR regulates recruitment of the postsynaptic scaffold. |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| SynGO annotation ID: | 1841 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |