| Annotated protein: | Potassium voltage-gated channel subfamily A member 3 (RCK3) (RGK5) (Voltage-gated potassium channel subunit Kv1.3) (Voltage-gated potassium channel subunit Kv3). Gene symbol: KCNA3. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P15384 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ KCNA3 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic membrane (GO:0099056) |
| Synapse type(s): | Calyx of Held |
| Annotated paper: | Ishikawa T, et al. "Distinct roles of Kv1 and Kv3 potassium channels at the calyx of Held presynaptic terminal" J Neurosci. 2003 Nov 12;23(32):10445-53 PMID:14614103 |
| Figure(s): | figure 5 |
| Annotation description: | Immunostaining in Calyx in wistar Rats. 21/2/2017 Pim: -Authors conclude presynaptic localization in the legend of Fig 5: " Immunofluorescence signals of Kv channels that overlapped with synaptophysin signals were taken as **presynaptic signals**, and their averaged intensities were determined by densitometric measurements (filled columns). " -"Integral" term derived form the TM domains in KCNA3. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 184 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |