| Annotated protein: | Germ cell-specific gene 1-like protein (GSG1-like protein). Gene symbol: GSG1L. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: D3ZK93 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GSG1L |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Schwenk J, et al. "High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes" Neuron. 2012 May 24;74(4):621-33 PMID:22632720 |
| Figure(s): | Figure 5G |
| Annotation description: | GSG1L is a transmembrane protein concentrated within the postsynaptic density of CA3 neurons in the adult (mouse or rat) hippocampus (Figure 5G). GSG1L is found <50nm from AMPAR subunits GluA2 and GluA4 (~60% GSG1L particles). Sparse labeling of GSG1L was detected in extrasynaptic sites |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Hana Goldschmidt (ORCID:0000-0002-5676-366X) Richard Huganir (ORCID:0000-0001-9783-5183) |
| Lab: | Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA and Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21205, USA |
| SynGO annotation ID: | 1838 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |