| Annotated protein: | Neuronal pentraxin receptor. Gene symbol: NPTXR. Taxonomy: Homo sapiens (Human). Uniprot ID: O95502 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NPTXR |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic neurotransmitter receptor activity (GO:0098962) |
| Synapse type(s): | brain, glutamatergic |
| Annotated paper: | Lee SJ, et al. "Presynaptic Neuronal Pentraxin Receptor Organizes Excitatory and Inhibitory Synapses" J Neurosci. 2017 Feb 1;37(5):1062-1080 PMID:27986928 |
| Figure(s): | Figs. 2, 3 |
| Annotation description: | Presynaptic NPR directly binds to the GluA1-N terminal extracellular domain and stimulates assembly of both excitatory and inhibitory postsynaptic sites. Loss of NPR suppressed surface GluA1 levels, and impaired excitatory synaptic transmission, without affecting synapse numbers. Fig.2 shows that NPR binds the GluA1-NTD. Fig.3: NPR, NP1, and NARP binding enhances GluA1 function. |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Electrophysiology (generic) IP + WB/MSMS |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| SynGO annotation ID: | 1836 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |