| Annotated protein: | Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (EC 3.2.2.6) (Interleukin-33 receptot beta chain). Gene symbol: IL1RAP. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q61730-3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ IL1RAP |
| Ontology domain: | Biological Process |
| SynGO term: | synapse adhesion between pre- and post-synapse (GO:0099560) |
| Synapse type(s): | cerebral cortex, glutamatergic |
| Annotated paper: | Yoshida T, et al. "Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule" J Neurosci. 2012 Feb 22;32(8):2588-600 PMID:22357843 |
| Figure(s): | Fig. 6 |
| Annotation description: | Fig.6 The ECD of IL-1RAcP and IL-1RAcPb bind the PTPδ ECD Authors note: - Adhesion is measured in a cell aggregation assay on a sensor chip. - The referenced figures show adhesive properties in non-neuronal cells. The functional relevance for synapse formation between these pre- and postsynaptic proteins is represented in other tickets based on this paper. |
| Evidence tracking, Biological System: | Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| SynGO annotation ID: | 1832 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |