| Annotated protein: | Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48). Gene symbol: PTPRD. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q64487 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PTPRD |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic density assembly (GO:0099151) |
| Synapse type(s): | cerebral cortex, glutamatergic |
| Annotated paper: | Yoshida T, et al. "Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule" J Neurosci. 2012 Feb 22;32(8):2588-600 PMID:22357843 |
| Figure(s): | Fig. 6, 9 |
| Annotation description: | Fig.6 The ECD of IL-1RAcP and IL-1RAcPb bind the PTPδ ECD Fig.9 PTPδ induces postsynaptic differentiation through IL-1RAcPb (shown with PTPδA3-ECD-Fc beads on neurons of wild-type (Il1rap+/+) and IL-1RAcP knock-out (Il1rap-/-) mice) |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Protein-protein interaction (generic) |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| SynGO annotation ID: | 1829 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |