| Annotated protein: | Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (EC 3.2.2.6) (Interleukin-33 receptot beta chain). Gene symbol: IL1RAP. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q61730-3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ IL1RAP |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic density assembly (GO:0099151) |
| Synapse type(s): | cerebral cortex, glutamatergic |
| Annotated paper: | Yoshida T, et al. "Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule" J Neurosci. 2012 Feb 22;32(8):2588-600 PMID:22357843 |
| Figure(s): | Fig.9 |
| Annotation description: | Fig.9 PTPδ induces postsynaptic differentiation through IL-1RAcPb (shown with PTPδA3-ECD-Fc beads on neurons of wild-type (Il1rap+/+) and IL-1RAcP knock-out (Il1rap-/-) mice) 3/11/2017 Pim - The role of IL-1RAcPb is studied via a Il1rap KO animal and rescue with overexpression of IL-1RAcP or IL-1RAcPb. Only IL-1RAcPb was able to rescue the phenotype of defective postsynaptic differentiation. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| SynGO annotation ID: | 1827 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |