Annotated protein:	Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48). Gene symbol: PTPRD. Taxonomy: Homo sapiens (Human). Uniprot ID: P23468
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SynGO gene info:	SynGO data @ PTPRD
Ontology domain:	Biological Process
SynGO term:	presynapse assembly (GO:0099054)
Synapse type(s):	hippocampus, glutamatergic
Annotated paper:	Valnegri P, et al. "The X-linked intellectual disability protein IL1RAPL1 regulates excitatory synapse formation by binding PTPdelta and RhoGAP2" Hum Mol Genet. 2011 Dec 15;20(24):4797-809 PMID:21926414
Figure(s):	Fig.3, 6
Annotation description:	7/6/2017 Pim Fig.3: The extracellular domain of IL1RAPL1 interacts with that of PTPδ. Fig.6: The IL1RAPL1/PTPδ complex recruits RhoGAP2 to synapses. - PTPδ is a presynaptic protein, IL1RAPL1 is a postsynaptic protein, the complex formation can be seen as a handshaking between synaptic compartment and is considered as a 'signal'. The term 'trans-synaptic signaling by trans-synaptic complex (GO:0099545)' was applied. - The role of PTPδ is not examined to the same extent as that of IL1RAPL1 int his paper. The application of the term 'trans-synaptic signaling by trans-synaptic complex (GO:0099545)' comes from the specificity of PTPδ as a presynaptic partner of IL1RAPL1 as shown in Fig.3.
Evidence tracking, Biological System:	Cultured neurons Non-neuronal tissue
Evidence tracking, Protein Targeting:	Over-expression
Evidence tracking, Experiment Assay:	Confocal IP + WB/MSMS
Annotator(s):	Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523)
Lab:	CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy
Additional literature:	Shows similar data on the IL-1RAcP and IL-1RAcPb interactions. @ PMID:22357843
SynGO annotation ID:	1826
Dataset release (version):	20231201
View annotation as GO-CAM model: