| Annotated protein: | X-linked interleukin-1 receptor accessory protein-like 2 (IL-1 receptor accessory protein-like 2) (IL-1-RAPL-2) (IL-1RAPL-2) (IL1RAPL-2) (EC 3.2.2.6) (IL1RAPL-2-related protein) (Interleukin-1 receptor 9) (IL-1R-9) (IL-1R9) (Three immunoglobulin domain-containing IL-1 receptor-related 1) (TIGIRR-1). Gene symbol: IL1RAPL2. Taxonomy: Homo sapiens (Human). Uniprot ID: Q9NP60 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ IL1RAPL2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of presynapse assembly (GO:1905606) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Valnegri P, et al. "The X-linked intellectual disability protein IL1RAPL1 regulates excitatory synapse formation by binding PTPdelta and RhoGAP2" Hum Mol Genet. 2011 Dec 15;20(24):4797-809 PMID:21926414 |
| Figure(s): | Fig. 1e,f,g,h; Fig. 2 |
| Annotation description: | Fig. 1e,f,g,h; overexpression of IL1RAPL2 in hippocampal neurons promotes excitatory but not inhibitory synapses formation Literal: "Similar to IL1RAPL1, IL1RAPL2 over-expression increased the dendritic spine number without affecting morphology" Fig. 2; IL1RAPL1 and IL1RAPL2 promote functional excitatory synapse formation. Literal: "IL1RAPL1 and IL1RAPL2 are able to induce synapsin I clustering in contacting axons of co-cultured neurons." 7/6/2017 Pim - The term "presynapse assembly" is allowed over "synapse assembly" because of the experiments in non-neuronal cels where expressed IL1RAPL1 is able to induce aggregation of presynaptic marker proteins. - Data in this paper does NOT sufficiently claim a role in transsynaptic signaling as show and claimed for the IL1RAPL1 paralog in additional figures. |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| SynGO annotation ID: | 1824 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |