Annotated protein:	Interleukin-1 receptor accessory protein-like 1 (IL-1-RAPL-1) (IL-1RAPL-1) (IL1RAPL-1) (EC 3.2.2.6) (Oligophrenin-4) (Three immunoglobulin domain-containing IL-1 receptor-related 2) (TIGIRR-2) (X-linked interleukin-1 receptor accessory protein-like 1). Gene symbol: IL1RAPL1. Taxonomy: Homo sapiens (Human). Uniprot ID: Q9NZN1
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SynGO gene info:	SynGO data @ IL1RAPL1
Ontology domain:	Biological Process
SynGO term:	trans-synaptic signaling by trans-synaptic complex (GO:0099545)
Synapse type(s):	hippocampus, glutamatergic
Annotated paper:	Valnegri P, et al. "The X-linked intellectual disability protein IL1RAPL1 regulates excitatory synapse formation by binding PTPdelta and RhoGAP2" Hum Mol Genet. 2011 Dec 15;20(24):4797-809 PMID:21926414
Figure(s):	Fig.3, 5, 6
Annotation description:	7/6/2017 Pim Fig.3: The extracellular domain of IL1RAPL1 interacts with that of PTPδ. Fig.6: The IL1RAPL1/PTPδ complex recruits RhoGAP2 to synapses. Fig.5: RhoGAP2 increases the number of synapses and the accumulation of endogenous synaptic proteins. - PTPδ is a presynaptic protein, IL1RAPL1 is a postsynaptic protein, the complex formation can be seen as a handshaking between synaptic compartment and is considered as a 'signal'. The term 'trans-synaptic signaling by trans-synaptic complex (GO:0099545)' was applied.
Evidence tracking, Biological System:	Cultured neurons Non-neuronal tissue
Evidence tracking, Protein Targeting:	Over-expression
Evidence tracking, Experiment Assay:	Confocal IP + WB/MSMS
Annotator(s):	Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523)
Lab:	CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy
Additional literature:	Similar results were reported in this paper @ PMID:21940441
SynGO annotation ID:	1823
Dataset release (version):	20231201
View annotation as GO-CAM model: