| Annotated protein: | Unconventional myosin-Vb (Myosin heavy chain myr 6). Gene symbol: MYO5B. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P70569 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ MYO5B |
| Ontology domain: | Biological Process |
| SynGO term: | neurotransmitter receptor transport, endosome to plasma membrane (GO:0099639) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Wang Z, et al. "Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity" Cell. 2008 Oct 31;135(3):535-48 PMID:18984164 |
| Figure(s): | Fig. 6 |
| Annotation description: | Fig.6: - MyoVb is Required for LTP-Induced Spine Exocytosis. Tested with optical physiology using a TfR-superecliptic pHluorin. - Disrupting MyoVb Prevents Both AMPA Receptor Delivery and Spine Growth Following LTP Stimuli. Tested with optical physiology using a GluR1-superecliptic pHluorin. 3/11/2017 Pim - I have decided against functionally linking role in RE-localization to the the observed phenomena of AMPAR insertion and spine morphology since not directly shown in paper. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Optical physiology |
| Annotator(s): | Harold MacGillavry (ORCID:0000-0002-6153-3586) Casper Hoogenraad (ORCID:0000-0002-2666-0758) |
| Lab: | Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands |
| SynGO annotation ID: | 1808 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |