| Annotated protein: | Unconventional myosin-Vb (Myosin heavy chain myr 6). Gene symbol: MYO5B. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P70569 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ MYO5B |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of modification of postsynaptic structure (GO:0099159) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Wang Z, et al. "Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity" Cell. 2008 Oct 31;135(3):535-48 PMID:18984164 |
| Figure(s): | Fig. 6 |
| Annotation description: | Fig.6: - Disrupting MyoVb Prevents Both AMPA Receptor Delivery and Spine Growth Following LTP Stimuli. Tested with optical physiology using a GluR1-superecliptic pHluorin. Literal: "Next we examined the role of MyoVb in acute spine structural remodeling by assaying glycine-induced growth of dendritic spines in live neurons. In control neurons, glycine LTP was accompanied by an expansion of existing spines and growth of new dendritic spines that was dependent on activation of NMDA receptors (Figures 6F-H). In contrast, glycine-induced spine growth was absent upon MyoVb knock down, and this effect was fully rescued by co-expression of RNAi-resistant MyoVb-WT (Figures 6F-H)" 3/11/2017 Pim - I have decided against functionally linking role in RE-localization to the the observed phenomena of AMPAR insertion and spine morphology since not directly shown in paper. - Because the experiments include a discrete stimulus (glycine-induced LTP) the "modulation of..." term was applied. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Harold MacGillavry (ORCID:0000-0002-6153-3586) Casper Hoogenraad (ORCID:0000-0002-2666-0758) |
| Lab: | Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands |
| SynGO annotation ID: | 1806 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |