| Annotated protein: | Unconventional myosin-Vb (Myosin heavy chain myr 6). Gene symbol: MYO5B. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P70569 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ MYO5B |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic recycling endosome membrane (GO:0098944) |
| Synapse type(s): | hippocampus, glutamatergic Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Wang Z, et al. "Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity" Cell. 2008 Oct 31;135(3):535-48 PMID:18984164 |
| Figure(s): | Fig. 2, 3 |
| Annotation description: | Fig.2: Activation of Synaptic NMDA Receptors Recruits MyoVb to REs (recycling endosomes) Fig.3: Ca2+-Dependent Unfolding and Binding of MyoVb to the RE Adaptor Rab11-FIP2 |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal IP + WB/MSMS |
| Annotator(s): | Harold MacGillavry (ORCID:0000-0002-6153-3586) Casper Hoogenraad (ORCID:0000-0002-2666-0758) |
| Lab: | Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands |
| SynGO annotation ID: | 1804 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |