Annotated protein: | Grip2 protein. Gene symbol: GRIP2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q499W6 |
antibody wiki: | |
SynGO gene info: | SynGO data @ GRIP2 |
Ontology domain: | Biological Process |
SynGO term: | neurotransmitter receptor transport, endosome to postsynaptic membrane (GO:0098887) |
Synapse type(s): | cerebral cortex, glutamatergic |
Annotated paper: | Mao L, et al. "GRIP1 and 2 regulate activity-dependent AMPA receptor recycling via exocyst complex interactions" Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19038-43 PMID:20956289 |
Figure(s): | Figure 1-5 |
Annotation description: | This paper describes experiments on GRIP1/2 double-knockout neurons demonstrating that GRIP1 is required for activity-induced recycling of AMPARs (but not endocytosis or steady-state AMAPR surface levels), and that GRIP1 is associated with endosomes, as well as proteins of the exocyst complex targeting AMPAR-containing endosomes to the membrane. Together, these studies indicate that GRIP1 and 2 are required for AMPAR transport from endosomes to the postsynaptic membrane |
Evidence tracking, Biological System: | Cultured neurons |
Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
Evidence tracking, Experiment Assay: | Confocal Western blot Biochemical fractionation (generic) |
Annotator(s): | Harold MacGillavry (ORCID:0000-0002-6153-3586) Casper Hoogenraad (ORCID:0000-0002-2666-0758) |
Lab: | Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands |
SynGO annotation ID: | 1801 |
Dataset release (version): | 20231201 |
View annotation as GO-CAM model: |