Annotated protein:Grip2 protein. Gene symbol: GRIP2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q499W6
antibody wiki:
SynGO gene info:SynGO data @ GRIP2
Ontology domain:Biological Process
SynGO term:neurotransmitter receptor transport, endosome to postsynaptic membrane (GO:0098887)
Synapse type(s):cerebral cortex, glutamatergic
Annotated paper:Mao L, et al. "GRIP1 and 2 regulate activity-dependent AMPA receptor recycling via exocyst complex interactions" Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19038-43 PMID:20956289
Figure(s):Figure 1-5
Annotation description:This paper describes experiments on GRIP1/2 double-knockout neurons demonstrating that GRIP1 is required for activity-induced recycling of AMPARs (but not endocytosis or steady-state AMAPR surface levels), and that GRIP1 is associated with endosomes, as well as proteins of the exocyst complex targeting AMPAR-containing endosomes to the membrane. Together, these studies indicate that GRIP1 and 2 are required for AMPAR transport from endosomes to the postsynaptic membrane
Evidence tracking, Biological System:Cultured neurons
Evidence tracking, Protein Targeting:Genetic transformation (eg; knockout, knockin, mutations)
Evidence tracking, Experiment Assay:Confocal
Western blot
Biochemical fractionation (generic)
Annotator(s):Harold MacGillavry (ORCID:0000-0002-6153-3586)
Casper Hoogenraad (ORCID:0000-0002-2666-0758)
Lab:Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands
SynGO annotation ID:1801
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology