| Annotated protein: | Unconventional myosin-VI (Protein twist) (Unconventional myosin-6). Gene symbol: MYO6. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q64331 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ MYO6 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic neurotransmitter receptor endocytosis (GO:0098884) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Osterweil E, et al. "A role for myosin VI in postsynaptic structure and glutamate receptor endocytosis" J Cell Biol. 2005 Jan 17;168(2):329-38 PMID:15657400 |
| Figure(s): | Fig. 6, 7, 8 |
| Annotation description: | Fig.5: Myo6 exists in a complex with the AMPAR, AP-2, and SAP97 in rat brain Fig.6: Sv/sv hippocampal neurons display dysfunctional AMPA-induced AMPAR internalization Fig.7: Sv/sv hippocampal neurons display dysfunctional insulin-induced AMPAR internalization identical to the disruption of clathrin-mediated endocytosis |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Antibody (detection) |
| Evidence tracking, Experiment Assay: | Wide-field fluorescence IP + WB/MSMS |
| Annotator(s): | Harold MacGillavry (ORCID:0000-0002-6153-3586) Casper Hoogenraad (ORCID:0000-0002-2666-0758) |
| Lab: | Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands |
| SynGO annotation ID: | 1800 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |