| Annotated protein: | Potassium voltage-gated channel subfamily A member 1 (RBKI) (RCK1) (Voltage-gated potassium channel subunit Kv1.1). Gene symbol: KCNA1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P10499 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ KCNA1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic membrane (GO:0099055) |
| Synapse type(s): | brainstem, glutamatergic Calyx of Held |
| Annotated paper: | Ishikawa T, et al. "Distinct roles of Kv1 and Kv3 potassium channels at the calyx of Held presynaptic terminal" J Neurosci. 2003 Nov 12;23(32):10445-53 PMID:14614103 |
| Figure(s): | figure 5 |
| Annotation description: | Immunostaining in Calyx in wistar Rats. 22/1/2017 Pim: -Fig.5 bargraph: synaptophysin-colocalized Kv signal is regarded as presynaptic localization. The remaining signal (exlcluding the nucleus) is caused by Kv localized to the soma of MNTB cells; for the calyx of held these are considered to represent postsynaptic Kv channels. [see: http://www.nature.com/neuro/journal/v8/n4/images/nn0405-402-F1.gif] -"Intrinsic component ..." element derived from the TM domains of the Kv channel subunit. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 180 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |