| Annotated protein: | Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4). Gene symbol: KCNA4. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q61423 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ KCNA4 |
| Ontology domain: | Biological Process |
| SynGO term: | voltage-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099508) |
| Annotated paper: | Carrasquillo Y, et al. "A-type K+ channels encoded by Kv4.2, Kv4.3 and Kv1.4 differentially regulate intrinsic excitability of cortical pyramidal neurons" J Physiol. 2012 Aug 15;590(16):3877-90 PMID:22615428 |
| Figure(s): | fig 6 |
| Annotation description: | 14615029 (SynGO ID #13) fig 8G-J: Localisation in presynaptic terminal 22615428 fig 6: in the presence of Ba2+, mean ± SEM firing rates were significantly (P < 0.001) higher in Kv1.4-/- than in WT CP neurons Biochemical process is inferred from: localisation of the channel and its general function and effect on excitability. Evidence on excitability not from single synapses but from the whole neuron Specs 22615428: Species: Adult (4- to 8-week-old) wild-type (WT) mice and mice harbouring targeted genetic disruption of the Kcna4 (Kv1.4-/- ) (London et al. 1998), Kcnd2 (Kv4.2-/- ) (Guo et al. 2005) or Kcnd3 (Kv4.3-/-) (Niwa et al. 2008) locus were used in the experiments here. Process: in the presence of Ba2+, mean ± SEM firing rates were significantly (P < 0.001) higher in Kv1.4-/- than in WT CP neurons. rule: NAS_MFCC-BP rationale: Protein has voltage-gated ion channel activity and is localized in teh presynaptic membrane (show with high-resulution technique). The inference to term 'voltage-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099508)' is trivial and non-controversial. Pinf_CC: [Q61423] SyNGO ID 13 (PMID:22615428, EM) |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Non-tracable Author Statement (NAS): | This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors. |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 18 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |