Annotated protein: | Potassium voltage-gated channel subfamily A member 1 (RBKI) (RCK1) (Voltage-gated potassium channel subunit Kv1.1). Gene symbol: KCNA1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P10499 |
antibody wiki: | |
SynGO gene info: | SynGO data @ KCNA1 |
Ontology domain: | Cellular Component |
SynGO term: | integral component of presynaptic membrane (GO:0099056) |
Synapse type(s): | Calyx of Held |
Annotated paper: | Ishikawa T, et al. "Distinct roles of Kv1 and Kv3 potassium channels at the calyx of Held presynaptic terminal" J Neurosci. 2003 Nov 12;23(32):10445-53 PMID:14614103 |
Figure(s): | figure 5 |
Annotation description: | Immunostaining in Calyx in wistar Rats. 21/2/2017 Pim: -Authors conclude presynaptic localization in the legend of Fig 5: " Immunofluorescence signals of Kv channels that overlapped with synaptophysin signals were taken as **presynaptic signals**, and their averaged intensities were determined by densitometric measurements (filled columns). " -"Integral" term derived form the TM domains in KCNA1. |
Evidence tracking, Biological System: | Intact tissue |
Evidence tracking, Protein Targeting: | Antibody (detection) |
Evidence tracking, Experiment Assay: | Confocal |
Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
SynGO annotation ID: | 179 |
Dataset release (version): | 20231201 |
View annotation as GO-CAM model: |