| Annotated protein: | Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1). Gene symbol: GSK3B. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9WV60 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GSK3B |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | cerebral cortex, glutamatergic |
| Annotated paper: | Perez-Costas E, et al. "Light and electron microscopy study of glycogen synthase kinase-3beta in the mouse brain" PLoS One. 2010 Jan 27;5(1):e8911 PMID:20111716 |
| Figure(s): | Fig. 4F, Fig. 5C and E |
| Annotation description: | Fig. 4F, Fig. 5C and E, GSK3b staining is conspicuously present on the postsynaptic density. Literal: "In the neuropil, dense immunolabeling was found in postsynaptic densities in both dendrites and dendritic spines." "Figure 5. ... C) A labeled astrocytic process (a) is surrounding an unlabeled blood vessel (v). The basement membrane and endothelial cell are devoid of labeling. A dendrite (d) and a postsynaptic density (white arrowhead) are also labeled. Note that myelin is completely devoid of immunostaining (black star). ... E) Examples of two synapses. One is a GSK3b-labeled synapse (white arrowhead), while the other synapse is unlabeled (black arrowhead)." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| SynGO annotation ID: | 1787 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |