| Annotated protein: | ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1). Gene symbol: GIT1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q68FF6 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GIT1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synaptic vesicle exocytosis (GO:2000300) |
| Synapse type(s): | Calyx of Held |
| Annotated paper: | Montesinos MS, et al. "Presynaptic Deletion of GIT Proteins Results in Increased Synaptic Strength at a Mammalian Central Synapse" Neuron. 2015 Dec 2;88(5):918-925 PMID:26637799 |
| Figure(s): | Fig. 2 a,b; Fig 2 c,d |
| Annotation description: | Fig 2 a,b Synaptic Plasticity Is Altered by the Loss of GIT Expression Literal "Figure 2 shows that at all frequencies tested there was a significant reduction in the PPR in both the Git1-/- or Git1-/-Git2-/- calyces, but not the Git2-/- Fig 2c,d GIT1 regulates frequency dependent synaptic plasticity. Literal "We found an increase in the rate of onset of depression and lower steady state levels with the loss of GIT1 alone, and this amount of depression was not increased with loss of both GIT1 and GIT2 together 10/11/2017 Pim - Git1 was deleted in the presynapse specifically, but GIT2 was a global KO. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Electrophysiology (generic) |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| SynGO annotation ID: | 1783 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |