| Annotated protein: | Cadherin-2 (Neural cadherin) (N-cadherin). Gene symbol: CDH2. Taxonomy: Gallus gallus (Chicken). Uniprot ID: P10288 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CDH2 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic membrane (GO:0099056) |
| Synapse type(s): | midbrain |
| Annotated paper: | Uchida N, et al. "The catenin/cadherin adhesion system is localized in synaptic junctions bordering transmitter release zones" J Cell Biol. 1996 Nov;135(3):767-79 PMID:8909549 |
| Figure(s): | Fig7E/F, Fig.8 |
| Annotation description: | 2/11/2017 Pim - Authors show N-cadherin labeling of the synaptic cleft outside of the area defined by the active zone and PSD (Fig.7E). The authors interpret this labeling as to originate from N-cadherin proteins intergral to the plasm membranes of the pre- and postsynaptic compartments. They do this based on the observations that 1) N-cadherin interacts with intracellular alphaN-catenin protein (Fig.8) and that 2) alphaN-catenin is present at the interface of the presynaptic as well as the postsynaptic plasma membrane at a region reminiscent of the N-cadherin area (Fig.7F; no double staining was used). - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy IP + WB/MSMS |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| SynGO annotation ID: | 1774 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |