| Annotated protein: | FERM, ARHGEF and pleckstrin domain-containing protein 1 (FERM, RhoGEF and pleckstrin domain-containing protein 1). Gene symbol: FARP1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: F1LYQ8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ FARP1 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic actin cytoskeleton organization (GO:0098974) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Cheadle L, et al. "The novel synaptogenic protein Farp1 links postsynaptic cytoskeletal dynamics and transsynaptic organization" J Cell Biol. 2012 Dec 10;199(6):985-1001 PMID:23209303 |
| Figure(s): | Figs.7, 8 |
| Annotation description: | Fig.7C,D shows that Farp1 regulates postsynaptic Rac1 using an optical probe for Rac1 activity, with knockdown of Farp1 reducing Rac1 activity and overexpression of Farp1 increasing it. Farp1 promotes steady-state spine F-actin amounts as shown in Fig.8A,B,D and F-actin assembly in spines as shown in Fig. 8C,D. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal FRET |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| SynGO annotation ID: | 1773 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |