Annotated protein:	Neurexin-3-beta (Neurexin III-beta) [Cleaved into: Neurexin-3-beta, soluble form; Neurexin-3-beta, C-terminal fragment (NRXN3-CTF)]. Gene symbol: NRXN3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8C985
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SynGO gene info:	SynGO data @ NRXN3
Ontology domain:	Biological Process
SynGO term:	presynaptic modulation of chemical synaptic transmission (GO:0099171)
Synapse type(s):	olfactory bulb, GABAergic
Annotated paper:	Aoto J, et al. "Distinct circuit-dependent functions of presynaptic neurexin-3 at GABAergic and glutamatergic synapses" Nat Neurosci. 2015 Jul;18(7):997-1007 PMID:26030848
Figure(s):	Figs. 6, 7
Annotation description:	In inhibitory olfactory bulb synapses, the neurexin-3a/b deletion caused a selective decrease in presynaptic GABA release (Fig. 7) without a change in postsynaptic receptor composition (Fig. 6). 1/11/2017 Pim - The paper uses DKO of neurexin-3alpha and neurexin-3beta genes (Fig.6/7) Data on the neurexin-3alpha is also included in Supplementary Fig. 2. Overall, the data for this paper directly supports a role for neurexin-3alpha, and a IGI relation of neurexin-3beta that is based on supposed functional redundancy between paralogs and author intent.
Evidence tracking, Biological System:	Intact tissue
Evidence tracking, Protein Targeting:	Genetic transformation (eg; knockout, knockin, mutations)
Evidence tracking, Experiment Assay:	Electrophysiology (generic)
Annotator(s):	Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863)
Lab:	Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA
Additional literature:	This study highlights that neurexins have diverse functional roles that are synapse-type specific. Functional roles of individual neurexins are therefore not generally applicable across synapses types. @ PMID:28472659
SynGO annotation ID:	1770
Dataset release (version):	20231201
View annotation as GO-CAM model: