| Annotated protein: | Neuronal pentraxin-2 (NP2) (Neuronal pentraxin II) (NP-II). Gene symbol: NPTX2. Taxonomy: Homo sapiens (Human). Uniprot ID: P47972 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NPTX2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic neurotransmitter receptor activity (GO:0098962) |
| Synapse type(s): | glutamatergic |
| Annotated paper: | Lee SJ, et al. "Presynaptic Neuronal Pentraxin Receptor Organizes Excitatory and Inhibitory Synapses" J Neurosci. 2017 Feb 1;37(5):1062-1080 PMID:27986928 |
| Figure(s): | Figs. 2, 3 |
| Annotation description: | Fig.2: The extracellular domains of neuronal pentraxin receptor (NPR-ECD) and the secreted neuronal pentraxins NP1 and NARP (NP2) directly bind to GluA1-NTD Fig.3: NPR, NP1, and NARP binding enhances GluA1 function. 1/11/2017 Pim - The action of NP2 is not shown in synaptic setting but in HEK cells. The function of NP2 is inferred to also take place on synaptic AMPARs. |
| Evidence tracking, Biological System: | Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Wide-field fluorescence Whole-cell patch clamp IP + WB/MSMS |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| SynGO annotation ID: | 1769 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |