Annotated protein:Neuronal pentraxin-1 (NP1) (Neuronal pentraxin I) (NP-I). Gene symbol: NPTX1. Taxonomy: Homo sapiens (Human). Uniprot ID: Q15818
antibody wiki:
SynGO gene info:SynGO data @ NPTX1
Ontology domain:Biological Process
SynGO term:regulation of postsynaptic neurotransmitter receptor activity (GO:0098962)
Synapse type(s):glutamatergic
Annotated paper:Lee SJ, et al. "Presynaptic Neuronal Pentraxin Receptor Organizes Excitatory and Inhibitory Synapses" J Neurosci. 2017 Feb 1;37(5):1062-1080 PMID:27986928
Figure(s):Figs. 2, 3
Annotation description:Fig.2: The extracellular domains of neuronal pentraxin receptor (NPR-ECD) and the secreted neuronal pentraxins NP1 and NARP (NP2) directly bind to GluA1-NTD
Fig.3: NPR, NP1, and NARP binding enhances GluA1 function.

1/11/2017 Pim
- The action of NP1 is not shown in synaptic setting but in HEK cells. The function of NP1 is inferred to also take place on synaptic AMPARs.
Evidence tracking, Biological System:Non-neuronal tissue
Evidence tracking, Protein Targeting:Over-expression
Evidence tracking, Experiment Assay:Confocal
Wide-field fluorescence
Whole-cell patch clamp
IP + WB/MSMS
Annotator(s):Tony Cijsouw (ORCID:0000-0003-0912-1514)
Thomas Biederer (ORCID:0000-0002-3670-7863)
Lab:Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA
SynGO annotation ID:1768
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology