| Annotated protein: | Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]. Gene symbol: ERBB4. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q61527 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ERBB4 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic membrane (GO:0099056) |
| Synapse type(s): | hippocampus, GABAergic |
| Annotated paper: | Fazzari P, et al. "Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling" Nature. 2010 Apr 29;464(7293):1376-80 PMID:20393464 |
| Figure(s): | Fig.1, Suppl Fig. 6a |
| Annotation description: | Fig.1: "j, Immunogold labelling (arrows) localizes ErbB4 to inhibitory boutons (ib) contacting the AIS of pyramidal neurons, and postsynaptic to excitatory boutons (eb) contacting the dendrites of interneurons (id) in hippocampus." 1/11/2017 Pim - Localization to plasma membrane is clear from the EM pictures - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| SynGO annotation ID: | 1766 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |