Annotated protein:Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]. Gene symbol: ERBB4. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q61527
antibody wiki:
SynGO gene info:SynGO data @ ERBB4
Ontology domain:Cellular Component
SynGO term:integral component of presynaptic membrane (GO:0099056)
Synapse type(s):hippocampus, GABAergic
Annotated paper:Fazzari P, et al. "Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling" Nature. 2010 Apr 29;464(7293):1376-80 PMID:20393464
Figure(s):Fig.1, Suppl Fig. 6a
Annotation description:Fig.1: "j, Immunogold labelling (arrows) localizes ErbB4 to inhibitory
boutons (ib) contacting the AIS of pyramidal neurons, and postsynaptic to
excitatory boutons (eb) contacting the dendrites of interneurons (id) in
hippocampus."

1/11/2017 Pim
- Localization to plasma membrane is clear from the EM pictures
- Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen.
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Electron Microscopy
Confocal
Annotator(s):Tony Cijsouw (ORCID:0000-0003-0912-1514)
Thomas Biederer (ORCID:0000-0002-3670-7863)
Lab:Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA
SynGO annotation ID:1766
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology