Annotated protein:Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]. Gene symbol: ERBB4. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q61527
antibody wiki:
SynGO gene info:SynGO data @ ERBB4
Ontology domain:Biological Process
SynGO term:synapse assembly (GO:0007416)
Synapse type(s):neocortex, GABAergic
Annotated paper:Fazzari P, et al. "Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling" Nature. 2010 Apr 29;464(7293):1376-80 PMID:20393464
Figure(s):Fig. 3c-e, g, h. Fig.4
Annotation description:Loss of ErbB4 in cortical PV+ interneurons impairs their ability to form inhibitory terminals (Fig. 3c-e, g, h), suggesting that ErbB4 acts presynaptically to establish GABAergic synapses onto pyramidal neurons in the cortex. In addition, loss of ErbB4 in PV+ interneurons reduced the number of excitatory synapses they receive, indicating postsynaptic roles of ErbB4 in the control of excitatory synaptic inputs to PV+ cells.
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Genetic transformation (eg; knockout, knockin, mutations)
Evidence tracking, Experiment Assay:Confocal
Field recordings
Annotator(s):Tony Cijsouw (ORCID:0000-0003-0912-1514)
Thomas Biederer (ORCID:0000-0002-3670-7863)
Lab:Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA
SynGO annotation ID:1765
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology