| Annotated protein: | Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]. Gene symbol: ERBB4. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q61527 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ERBB4 |
| Ontology domain: | Biological Process |
| SynGO term: | synapse assembly (GO:0007416) |
| Synapse type(s): | neocortex, GABAergic |
| Annotated paper: | Fazzari P, et al. "Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling" Nature. 2010 Apr 29;464(7293):1376-80 PMID:20393464 |
| Figure(s): | Fig. 3c-e, g, h. Fig.4 |
| Annotation description: | Loss of ErbB4 in cortical PV+ interneurons impairs their ability to form inhibitory terminals (Fig. 3c-e, g, h), suggesting that ErbB4 acts presynaptically to establish GABAergic synapses onto pyramidal neurons in the cortex. In addition, loss of ErbB4 in PV+ interneurons reduced the number of excitatory synapses they receive, indicating postsynaptic roles of ErbB4 in the control of excitatory synaptic inputs to PV+ cells. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal Field recordings |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| SynGO annotation ID: | 1765 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |