| Annotated protein: | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2). Gene symbol: ERBIN. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q80TH2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ERBIN |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Tao Y, et al. "Erbin interacts with TARP gamma-2 for surface expression of AMPA receptors in cortical interneurons" Nat Neurosci. 2013 Mar;16(3):290-9 PMID:23354328 |
| Figure(s): | Fig 4a |
| Annotation description: | Fig.3 "Notably, Erbin was enriched in puncta in dendritic shafts of interneurons (Supplementary Fig. 2b), suggesting localization in postsynaptic compartments. We observed PSD95 co-staining in 88.2 ± 2.3% of Erbin-positive puncta (Fig. 3a), indicating that the majority of Erbin puncta are localized at excitatory synapses. " ... "Together, these observations suggest that Erbin is localized in the postsynaptic compartments of excitatory synapses in GABAergic neurons " |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| SynGO annotation ID: | 1764 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |