| Annotated protein: | Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin-2). Gene symbol: ADGRL2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8JZZ7 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ADGRL2 |
| Ontology domain: | Biological Process |
| SynGO term: | synapse organization (GO:0050808) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Anderson GR, et al. "Postsynaptic adhesion GPCR latrophilin-2 mediates target recognition in entorhinal-hippocampal synapse assembly" J Cell Biol. 2017 Nov 6;216(11):3831-3846 PMID:28972101 |
| Figure(s): | Figs. 2, 4, 5 |
| Annotation description: | Latrophilin-2 loss in postsynaptic hippocampal neurons cultured from KO mice reduced spine density and staining for excitatory markers but not inhibitory synapses, as shown in Fig. 2B-J. In agreement, Fig. 2K,L shows that postsynaptic loss of latrophilin-2 in cultured hippocampal neurons reduces the frequency and amplitude of excitatory miniature events. Fig. 4 shows that latrophilin-2 is also required in vivo for normal spine numbers and its loss reduces spine numbers in CA1 stratum lacunosum moleculare, where it is expressed, but not in other strata. This region-specific effect on functional synapse assembly is supported by the result that postsynaptic Lphn2 deletion in CA1 impairs excitatory synaptic transmission of entorhinal cortex inputs, shown in Fig. 5. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal Field recordings |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| SynGO annotation ID: | 1759 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |