Annotated protein:	Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin-2). Gene symbol: ADGRL2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8JZZ7
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SynGO gene info:	SynGO data @ ADGRL2
Ontology domain:	Cellular Component
SynGO term:	integral component of postsynaptic membrane (GO:0099055)
Synapse type(s):	hippocampus, glutamatergic
Annotated paper:	Anderson GR, et al. "Postsynaptic adhesion GPCR latrophilin-2 mediates target recognition in entorhinal-hippocampal synapse assembly" J Cell Biol. 2017 Nov 6;216(11):3831-3846 PMID:28972101
Figure(s):	Figs. 1, 3
Annotation description:	The localization of a Venus-tagged latrophilin-2 in knock-in mice in Fig. 1D-G shows a dendritic expression in CA1 with a dendrite domain-specific expression in the stratum lacunosum moleculare, where CA1 neurons receive inputs from entorhinal cortex. Fig. 3D,E shows that latrophilin-2 localizes to dendritic spines in this stratum. 1/11/2017 Pim - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. - The resolution of the localization data in Fig.3 is insufficient to claim term 'integral component of postsynaptic membrane (GO:0099055)'. This is concluded from 1) its known role as a TM protein of the plasma membrane (Lphns are cell-adhesion molecules) and 2) the effect of postsynapse specific KD of the protein. Together this makes the selected term very plausible.
Evidence tracking, Biological System:	Intact tissue
Evidence tracking, Protein Targeting:	Genetic transformation (eg; knockout, knockin, mutations)
Evidence tracking, Experiment Assay:	Confocal
Annotator(s):	Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863)
Lab:	Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA
SynGO annotation ID:	1758
Dataset release (version):	20231201
View annotation as GO-CAM model: