Annotated protein:Diacylglycerol kinase theta (DAG kinase theta) (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta). Gene symbol: DGKQ. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q6P5E8
antibody wiki:
SynGO gene info:SynGO data @ DGKQ
Ontology domain:Cellular Component
SynGO term:postsynapse (GO:0098794)
Synapse type(s):forebrain
hippocampus, glutamatergic
Annotated paper:Goldschmidt HL, et al. "DGKtheta Catalytic Activity Is Required for Efficient Recycling of Presynaptic Vesicles at Excitatory Synapses" Cell Rep. 2016 Jan 12;14(2):200-7 PMID:26748701
Figure(s):Fig.1D/E/F/G
Annotation description:DGKθ is shown to primarily localize to Glut synapses (Fig.1E-G). Biochemical enrichment suggests localization to both pre- and postsynaptic compartments (Fig.D).
Evidence tracking, Biological System:Intact tissue
Cultured neurons
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Confocal
Western blot
Biochemical fractionation (generic)
Annotator(s):Hana Goldschmidt (ORCID:0000-0002-5676-366X)
Richard Huganir (ORCID:0000-0001-9783-5183)
Lab:Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA and Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21205, USA
SynGO annotation ID:1752
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology