| Annotated protein: | Diacylglycerol kinase theta (DAG kinase theta) (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta). Gene symbol: DGKQ. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q6P5E8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DGKQ |
| Ontology domain: | Cellular Component |
| SynGO term: | presynapse (GO:0098793) |
| Synapse type(s): | forebrain hippocampus, glutamatergic |
| Annotated paper: | Goldschmidt HL, et al. "DGKtheta Catalytic Activity Is Required for Efficient Recycling of Presynaptic Vesicles at Excitatory Synapses" Cell Rep. 2016 Jan 12;14(2):200-7 PMID:26748701 |
| Figure(s): | Fig.1D/E/F/G |
| Annotation description: | DGKθ is shown to primarily localize to Glut synapses (Fig.1E-G). Biochemical enrichment suggests localization to both pre- and postsynaptic compartments (Fig.D). |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot Biochemical fractionation (generic) |
| Annotator(s): | Hana Goldschmidt (ORCID:0000-0002-5676-366X) Richard Huganir (ORCID:0000-0001-9783-5183) |
| Lab: | Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA and Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21205, USA |
| SynGO annotation ID: | 1751 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |