| Annotated protein: | Potassium voltage-gated channel subfamily C member 4 (Raw3) (Voltage-gated potassium channel subunit Kv3.4). Gene symbol: KCNC4. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q63734 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ KCNC4 |
| Ontology domain: | Biological Process |
| SynGO term: | voltage-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099508) |
| Annotated paper: | Baranauskas G, et al. "Kv3.4 subunits enhance the repolarizing efficiency of Kv3.1 channels in fast-spiking neurons" Nat Neurosci. 2003 Mar;6(3):258-66 PMID:12592408 |
| Figure(s): | figure 3 |
| Annotation description: | Channel characterisation in Voltage-clamp of Kv3.4 channels expressed in HEK-cells. rule: NAS_MFCC-BP rationale: Protein has voltage-gated ion channel activity and is localized in teh presynaptic membrane (show with high-resolution technique). The inference to term 'voltage-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099508)' is trivial and non-controversial. Pinf_CC: [Q63734] SyNGO ID 173 (PMID:15207333, EM) |
| Evidence tracking, Biological System: | Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Non-tracable Author Statement (NAS): | This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors. |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 175 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |