| Annotated protein: | A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao). Gene symbol: AKAP9. Taxonomy: Homo sapiens (Human). Uniprot ID: Q99996 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ AKAP9 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic neurotransmitter receptor activity (GO:0098962) |
| Synapse type(s): | glutamatergic |
| Annotated paper: | Westphal RS, et al. "Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex" Science. 1999 Jul 2;285(5424):93-6 PMID:10390370 |
| Figure(s): | Fig 3, Fig 4 |
| Annotation description: | Researchers investigate the effect of yotiao on NMDA-mediated currents by performing whole-cell recordings of transfected HEK 293 cells over expressing NMDA (NR1A-containing) receptors alone or together with yotiao. NMDA currents were enhanced by application of a cAMP analog, and these were greater in the presence of yotiao. Since yotiao anchors the type I protein phosphatase (PP1), investigators also assessed whether the regulation of NMDA current by yotiao might involve PP1 activity. By pharmacologically blocking PP1 activity, authors show that tonic PP1 activity associated with yotiao negatively affects NMDA receptor-mediated current. |
| Evidence tracking, Biological System: | Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Maria Andres-Alonso (ORCID:0000-0002-1585-539X) Michael Kreutz (ORCID:0000-0003-0575-6950) |
| Lab: | RG Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany and Leibniz Group 'Dendritic Organelles and Synaptic Function', Center for Molecular Neurobiology, ZMNH, University MC, Hamburg-Eppendorf, Hamburg, 20251, Germany |
| SynGO annotation ID: | 1746 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |