| Annotated protein: | Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene c-Fyn) (p59-Fyn). Gene symbol: FYN. Taxonomy: Mus musculus (Mouse). Uniprot ID: P39688 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ FYN |
| Ontology domain: | Biological Process |
| SynGO term: | modulation of chemical synaptic transmission (GO:0050804) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Grant SG, et al. "Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice" Science. 1992 Dec 18;258(5090):1903-10 PMID:1361685 |
| Figure(s): | Fig. 4 |
| Annotation description: | Fig. 4 shows impaired LTP in FYN KO mice Literal: "(LTP was impaired in the CAl neurons of hippocampal slices from fyn- mice in both the field EPSP (Fig. 4A) and in the popu- lation spik"..."Whereas weak stimulation strengths during a tetanus produced robust LTP in slices from wild-type mice (149.6 + 18.2 percent), this protocol induced little or no LTP in slices from fyn- mice (108 +/- 7.6 percent) (Fig. 4B). However, when strong intensity stimulation was used during the tetanus, a reduced form of LTP (approxi- mately 50 percent of that observed in slices from wild-type animals) was evident (133 ? 9.3 percent in fyn-; 168.5 +/- 11.6 percent in wild-type) (Fig. 4C)" 9/11/2017 Pim - The activity of the NMDAR is not affected by Fyn: "These experiments suggest that the NMDA receptor in fyn- mice functions normally and that the synaptic depolarization of the postsynaptic cells produced by the input seems adequate to activate the NMDA receptor. We find the results most consistent with a modulatory defect in the sequence of steps subsequent to the activation of the NMDA receptor." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| Additional literature: | Fig. 4 shows that impairment of long-term potentiation in Fyn KO mice is rescued by introducing Fyn transgene @ PMID:9114065 |
| SynGO annotation ID: | 1741 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |