| Annotated protein: | Protocadherin 17. Gene symbol: PCDH17. Taxonomy: Mus musculus (Mouse). Uniprot ID: E9PXF0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PCDH17 |
| Ontology domain: | Biological Process |
| SynGO term: | synapse adhesion between pre- and post-synapse (GO:0099560) |
| Synapse type(s): | globus pallidus, GABAergic striatum, glutamatergic |
| Annotated paper: | Hoshina N, et al. "Protocadherin 17 regulates presynaptic assembly in topographic corticobasal Ganglia circuits" Neuron. 2013 Jun 5;78(5):839-54 PMID:23684785 |
| Figure(s): | Figure 4, Fig.S5, 6, S6, 7 |
| Annotation description: | 30/10/2017 Pim - Data in Fig.4 shows PCDH17-Mediated Intercellular Homophilic Interaction and Fig.S5, 6, S6, 7 show effects on synapse development. I would propose to create one BP ticket based on this paper against 'synapse adhesion between pre- and post-synapse (GO:0099560)'. I do not see what stage of synapse development is affected, so I do not annotate this more specifically. Fig.4: PCDH17-Mediated Intercellular Homophilic Interaction. Experiments show direct interaction of PCDH17 in trans (HEK cells) and co-localization with PCDH17 in co-cultured neurons. The adhesion term is derived from the know role of cadherins in cell adhesion. |
| Evidence tracking, Biological System: | Intact tissue Cell-free system |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Over-expression |
| Evidence tracking, Experiment Assay: | Electron Microscopy Wide-field fluorescence Whole-cell patch clamp IP + WB/MSMS |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| SynGO annotation ID: | 1740 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |