Annotated protein:Protocadherin 17. Gene symbol: PCDH17. Taxonomy: Mus musculus (Mouse). Uniprot ID: E9PXF0
antibody wiki:
SynGO gene info:SynGO data @ PCDH17
Ontology domain:Biological Process
SynGO term:synapse adhesion between pre- and post-synapse (GO:0099560)
Synapse type(s):globus pallidus, GABAergic
striatum, glutamatergic
Annotated paper:Hoshina N, et al. "Protocadherin 17 regulates presynaptic assembly in topographic corticobasal Ganglia circuits" Neuron. 2013 Jun 5;78(5):839-54 PMID:23684785
Figure(s):Figure 4, Fig.S5, 6, S6, 7
Annotation description:30/10/2017 Pim
- Data in Fig.4 shows PCDH17-Mediated Intercellular Homophilic Interaction and Fig.S5, 6, S6, 7 show effects on synapse development. I would propose to create one BP ticket based on this paper against 'synapse adhesion between pre- and post-synapse (GO:0099560)'. I do not see what stage of synapse development is affected, so I do not annotate this more specifically.

Fig.4: PCDH17-Mediated Intercellular Homophilic Interaction. Experiments show direct interaction of PCDH17 in trans (HEK cells) and co-localization with PCDH17 in co-cultured neurons. The adhesion term is derived from the know role of cadherins in cell adhesion.
Evidence tracking, Biological System:Intact tissue
Cell-free system
Evidence tracking, Protein Targeting:Genetic transformation (eg; knockout, knockin, mutations)
Over-expression
Evidence tracking, Experiment Assay:Electron Microscopy
Wide-field fluorescence
Whole-cell patch clamp
IP + WB/MSMS
Annotator(s):Noa Lipstein (ORCID:0000-0002-0755-5899)
Cordelia Imig (ORCID:0000-0001-7351-8706)
Vincent O'connor (ORCID:0000-0003-3185-5709)
Nils Brose (ORCID:0000-0003-0938-8534)
Lab:Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany
SynGO annotation ID:1740
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology