| Annotated protein: | Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene c-Fyn) (p59-Fyn). Gene symbol: FYN. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q62844 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ FYN |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density, intracellular component (GO:0099092) |
| Synapse type(s): | brain, glutamatergic |
| Annotated paper: | Won S, et al. "PSD-95 stabilizes NMDA receptors by inducing the degradation of STEP61" Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4736-44 PMID:27457929 |
| Figure(s): | Fig 2B |
| Annotation description: | Fig. 2B, shows the enrichment of FYN in the PSD fraction Literal: "(B) Adult rat brain was fractionated to isolate the SPM and PSD. Samples from each fraction (10 μg of protein per lane) were immunoblotted with STEP61, PSD-95, Fyn, β-actin, and synaptophysin antibodies." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Western blot Biochemical fractionation (generic) |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| Additional literature: | Fig. 5 shows the enrichment of FYN in brain PSD following ischemia and reperfusion. @ PMID:10724115 |
| SynGO annotation ID: | 1739 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |