| Annotated protein: | Potassium voltage-gated channel subfamily C member 1 (NGK2) (RAW2) (Voltage-gated potassium channel subunit Kv3.1) (Voltage-gated potassium channel subunit Kv4). Gene symbol: KCNC1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P25122 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ KCNC1 |
| Ontology domain: | Biological Process |
| SynGO term: | voltage-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099508) |
| Annotated paper: | Hernandez-Pineda R, et al. "Kv3.1-Kv3.2 channels underlie a high-voltage-activating component of the delayed rectifier K+ current in projecting neurons from the globus pallidus" J Neurophysiol. 1999 Sep;82(3):1512-28 PMID:10482766 |
| Figure(s): | figure 4 |
| Annotation description: | Ion channel function is shown by expressing channels in CHO cells. rule: NAS_MFCC-BP rationale: Protein has voltage-gated ion channel activity and is localized in teh presynaptic membrane (show with high-resolution technique). The inference to term 'voltage-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099508)' is trivial and non-controversial. Pinf_CC: [P25122] SyNGO ID 15 (PMID:20857303, EM) |
| Evidence tracking, Biological System: | Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Non-tracable Author Statement (NAS): | This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors. |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 172 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |