| Annotated protein: | Ephrin type-A receptor 7 (EC 2.7.10.1) (EPH homology kinase 3) (EHK-3). Gene symbol: EPHA7. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P54759 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ EPHA7 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | hippocampus, glutamatergic cerebral cortex, glutamatergic cerebellum, glutamatergic Schaffer collateral synapse (CA3->CA1) Mossy fiber synapse (DG->CA3) |
| Annotated paper: | Amegandjin CA, et al. "Regional expression and ultrastructural localization of EphA7 in the hippocampus and cerebellum of adult rat" J Comp Neurol. 2016 Aug 15;524(12):2462-78 PMID:26780036 |
| Figure(s): | Fig 4, Fig 6, Fig 7 |
| Annotation description: | Fig. 4, Fig. 6 and Fig. 7: The localization of EphA7 has been demonstrated to be in dendritic spines by EM immunostaining in CA1 stratum radiatum (Fig. 4), on CA3 pyramidal cell (Fig. 6) and in rat cerebellar cortex (Fig. 7) Literal: "In the hippocampus, as well as in the cerebellar cortex, the most frequent and obvious cell surface immunostaining was associated with dendritic spines, notably their PSDs (Figs. 4A-C, 7A,B)" "Occasional cell surface labeling was also found on the plasma membrane of pyramidal, granule, or Purkinje cell bodies and dendritic shafts. This labeling sometimes involved PSDs of synapses directly on somata (Fig. 6D,F) or dendritic shafts (Fig. 4D-F)," "On rare occasions, two dendritic spines, one labeled and one unlabeled, formed synapses with a single unlabeled axon terminal. Generally, the labeled synapses were qualified as asymmetric, since they showed a prominent PSD." 9/11/2017 Pim - Literal: "In the hippocampus, as well as in the cerebellar cortex, the most frequent and obvious cell surface immunostaining was associated with dendritic spines, notably their PSDs (Figs. 4A-C, 7A,B)." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| SynGO annotation ID: | 1718 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |