Annotated protein:	Septin-11. Gene symbol: SEPTIN11. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: B3GNI6
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SynGO gene info:	SynGO data @ SEPTIN11
Ontology domain:	Cellular Component
SynGO term:	postsynaptic specialization of symmetric synapse (GO:0099629)
Synapse type(s):	cerebellum, GABAergic
Annotated paper:	Li X, et al. "Septin 11 is present in GABAergic synapses and plays a functional role in the cytoarchitecture of neurons and GABAergic synaptic connectivity" J Biol Chem. 2009 Jun 19;284(25):17253-17265 PMID:19380581
Figure(s):	Fig1, Fig3 and Fig4
Annotation description:	Fig1: Septin 11 migrates with the "type II" PSD fraction in cellular fractionation experiments that is also positive for gephyrin, but negative for PSD-95, suggesting these are GABAergic PSDs. This is verified by confocal microscopy in Fig3, where colocalization of septin 11 with GAD terminals is observed (54±4%), more then with vGlut1 synapses (25±2%; numbers from text p17257). Similar numbers are found in cerebellum (Fig3O-S). This is further verified by 2 methods of immunoEM (pre- and post-embedding; Fig4) in the cerebellum where Septin 11 is found in the dendrite an spine neck of synapses (Fig4A-G and 4J-K), and in the spine and PSD-area of some type II symmetric synapses (Fig4H-I ). Labelling on was absent on the presynaptic side or in axons (text p17258).
Evidence tracking, Biological System:	Intact tissue Cultured neurons
Evidence tracking, Protein Targeting:	Antibody (detection)
Evidence tracking, Experiment Assay:	Electron Microscopy Confocal Biochemical fractionation (generic)
Annotator(s):	Jan van Weering (ORCID:0000-0001-5259-4945) Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:	Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:	1717
Dataset release (version):	20231201
View annotation as GO-CAM model: