| Annotated protein: | Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (PP1bp175) (Protein phosphatase 1 regulatory subunit 9A) (p180). Gene symbol: PPP1R9A. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: O35867 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PPP1R9A |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic actin cytoskeleton organization (GO:0098974) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Zito K, et al. "Induction of spine growth and synapse formation by regulation of the spine actin cytoskeleton" Neuron. 2004 Oct 14;44(2):321-34 PMID:15473970 |
| Figure(s): | Fig. 3-5 and 8 |
| Annotation description: | Neurabin is a known actin-binding protein (see Additional literature and others). Fig. 3: Expression of GFPNrbI(1-287) Increases Spine Length and Density Fig. 4: Actin Binding Domain of NrbI Is Sufficient for Spine Morphogenesis Fig. 5: GFP-NrbI(1-287) Causes Actin Polymerization Fig. 8. Spines Expressing GFPNrbI(1-287) Exhibited Increased Motility Together this shows that neurabin is a regulator of postsynaptic actin structure. Since there is no real mentioning of a stimulus, I chose the more general term 'postsynaptic actin cytoskeleton organization (GO:0098974)' rather than 'regulation of modification of postsynaptic actin cytoskeleton (GO:1905274)' |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Two-photon microscopy Fluorescence recovery after photobleaching (FRAP) |
| Annotator(s): | Jan van Weering (ORCID:0000-0001-5259-4945) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Title: "Neurabin: a novel neural tissue-specific actin filament-binding protein involved in neurite formation" @ PMID:9362513 |
| SynGO annotation ID: | 1710 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |